Biosynthetic Studies of A2E, a Major Fluorophore of RPE Lipofuscin
نویسندگان
چکیده
∗ This work was supported by the National Institutes of Health Grants 34509 (KN) and EY12951 (JRS), the Charina Foundation (JRS), the Macula Vision Research Foundation (JRS) and unrestricted funds from Research to Prevent Blindness. JRS is a recipient of a Research to Prevent Blindness Lew R. Wasserman Merit Award. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
منابع مشابه
Understanding RPE lipofuscin.
In the Research Highlight article titled ‘‘Rethinking A2E,’’ Smith et al. offer interpretations of the recent paper by Ablonczy et al., titled ‘‘Lack of Correlation Between the Spatial Distribution of A2E and Lipofuscin Fluorescence in the Human Retinal Pigment Epithelium.’’ Readers will benefit from further discussion. Although not acknowledged by Smith et al., RPE lipofuscin consists of multi...
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Increased accumulation of lipofuscin in cells of the retinal pigment epithelium (RPE) is seen in several forms of macular degeneration, a common cause of blindness in humans. A major fluorophore of lipofuscin is the toxic bis-retinoid, N-retinylidene-N-retinylethanolamine (A2E). Previously, we generated mice with a knockout mutation in the abcr gene. This gene encodes rim protein (RmP), an ATP-...
متن کاملRethinking A2E.
The article ‘‘Lack of correlation between the spatial distribution of A2E and lipofuscin fluorescence in the human retinal pigment epithelium,’’ by Ablonczy and colleagues, forces us to re-evaluate 2 decades of dogma, and has potentially profound implications for the role (or lack thereof) of the bisretinoid A2E in human retinal degenerations. Using the elegant new method of imaging mass spectr...
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PURPOSE To compare the Alcon AcrySof Natural (SN60AT) and AcrySof (SA60AT), the AMO Sensar (AR40e) and ClariFlex, and the Pfizer CeeOn Edge 911A intraocular lenses (IOLs) as to their ability to protect retinal pigment epithelial (RPE) cells from light damage mediated by the lipofuscin fluorophore A2E. SETTING Department of Ophthalmology, Columbia University, New York, New York, USA. METHODS...
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The lipofuscin that accumulates in retinal pigment epithelium (RPE) cells may play a role in the deterioration and death of RPE cells which is typical of atrophic age-related macular degeneration (AMD). In human RPE cells, the deposition of this aging pigment is already apparent by age 20,[1] and while it continues to increase until approximately age 70, thereafter it declines.[2±4] The major h...
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